WE ARE CANCER ASSASSINS Global Cancer Assassins Treating Metastatic and Recurrent Cancers via Novel and Innovative Therapies Unavailable to North American Patients

WE TREAT UNTREATABLE CANCERS

At ICCA Global, we specialize in late-stage metastatic, recurrent, and primary cancers—often deemed "untreatable" or palliative by many U.S. and Canadian cancer centers.

Our expertise delivers renewed hope through next-generation therapies that are frequently inaccessible in North America. Our comfortable, convenient outpatient program has been shown to yield measurable results: most patients complete daily treatment in just 2–3 weeks, followed by a CT scan within 5 weeks with the intent to confirm near or complete NED (no evidence of disease).

As a truly integrative cancer center, we go beyond conventional NCCN guidelines and clinically proven alternative therapies to offer the world's leading treatment options. Every therapy is FDA-approved or approved in its country of origin, supporting personalized, cutting-edge alternatives with strong healing potential.

With Southern California affiliates and our premier center in Tijuana, Baja California, Mexico, we pioneer integrative oncology—prioritizing dignity and individualized care for every patient.

Our mission is clear and life-changing:

  1. You reclaim hope and experience more precious moments with loved ones.
  2. You find relief as pain and discomfort subside.
  3. Circulating cancer cells are cleared from your body, giving you a renewed sense of safety.
  4. Cancer stem cells—the seeds of recurrence—are targeted and destroyed so that you can look forward with greater confidence.
  5. Treatment is designed so that your tumors greatly shrink or even disappear, and you regain control over your health and your future.
  6. Your immune system is expected to regain its natural balance and strength, empowering your body to protect against future recurrence while continuing to heal.

FivePOINTS Cancer Care™— our proprietary strategy—optimizes efficacy and safety for primary or metastatic solid tumors through this innovative, synergistic combination:

  • Bispecific EpCAM/CD3 Cancer Vaccine with Single-Dose Keytruda (Pembrolizumab, PD-1 Inhibitor): Targets EpCAM on tumor cells (prevalent in adenocarcinomas of the colon, breast, stomach, prostate, esophagus, liver, pancreas, and more). This dual-purpose action bridges T cells (via CD3) to EpCAM and then to the tumors, directly activating precise, coordinated cytotoxic attacks and boosting anti-tumor immunity. Keytruda blocks PD-1 checkpoints, preventing T-cell exhaustion and countering PD-L1 upregulation often triggered by bispecific engagement—synergistically amplifying T-cell persistence, cytotoxicity, and durability for deeper, longer-lasting responses against resistant disease.
  • Autologous Peripheral Blood Lymphocyte Infusion uses the patient's own T cells, reactivated and expanded ex vivo to target tumor antigens with enhanced specificity and cytotoxic power. This intensifies the immune assault on residual cells post-vaccination. Combined with Thymosin alpha-1, it promotes T-cell maturation, strengthens immunity, and combats cancer-driven suppression.
  • Hypofractionated Radiation Therapy with a Chemo-Sensitizing Agent shrinks tumor burden while priming immunity. Focused high-dose radiation causes DNA damage and immunogenic cell death (for example, in hepatic metastases), revealing tumor antigens. Agents such as capecitabine or oxaliplatin inhibit DNA repair, enhancing synergy and apoptosis. This outpatient approach minimizes disruption to daily life and helps patients recover faster, avoiding long hospital stays.
  • Allogeneic Natural Killer (NK) Cells Infuse donor NK cells—innate effectors that rapidly detect and destroy tumors via cytotoxic granules and cytokines, without prior sensitization—targeting residual circulating cells and broadening immune coverage.
  • Microwave Tumor Ablation (MWA): Minimally invasive, targeted destruction of solid tumors (liver, kidney, lung, prostate, breast) using microwave energy. It involves limited or percutaneous access, spares healthy tissue, reduces pain and side effects, enables quick outpatient sessions (~30 minutes), and promotes fast recovery with minimal scarring. Our outcomes show near-100% effective tumor destruction and robust survival.

These evidence-based protocols draw on the latest global advances in oncology and immunotherapy, using precise mechanisms, administration, and monitoring to provide hope and transformative results where conventional options fall short.

If you or a loved one is seeking new answers, we invite you to schedule a no-obligation consultation to discuss your unique case. Our compassionate team is here to listen and help you explore your options—reach out to take your next step toward renewed hope and healing.

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ICCA Global Breaking News

INTEGRATIVE METASTATIC & RECURRENT GLOBAL CANCER CARE

At ICCA Global, we are proud to offer integrative and alternative cancer treatments that go beyond the limitations of traditional care. Our goal is to provide hope and support to patients with Primary, Metastatic, and Recurrent cancers, even when other cancer centers may deem their cases "untreatable."

ICCA Global

Our mission is simple yet powerful: to extend life, alleviate pain and symptoms, and eradicate cancer stem cells to prevent recurrence.

We specialize in non-toxic and non-invasive cancer treatments that support the whole body while preserving and restoring quality of life.

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ICCA Global

FivePOINTS Cancer Care™

Our innovative FivePOINTS Cancer Care™ program is a game-changer. It's a personalized treatment plan that harnesses the power of the most advanced therapies from around the world. We don't settle for outdated standards. We're forging a new path, redefining what is possible in your fight against cancer.

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We offer the highest standard of cancer therapies, pain management and palliative care with FivePOINTS Cancer Care™. Providing every patient with:

Greg DiRienzo

GREGORY DIRIENZO

FOUNDER OF ICCA GLOBAL CANCER CENTERS

At ICCA Global, we understand that every patient's journey is unique, which is why we offer cutting-edge cancer treatments that may not be available elsewhere. We are transforming the way cancer is treated globally.

My mission has always been to leave this place a better world than when I found it.

Cancers We Treat

At ICCA Global, we provide comprehensive cancer treatment for all stages, from early to advanced.

Cancers we treat, among others include:

Bladder
Bone
Breast
Colon
Colorectal
Esophageal
Head & Neck
Liver
Lung
Ovarian / Uterine
Pancreatic
Prostate
Sarcomas
Stomach

ICCA Global Offers HOPE when HOPE is Lost!

Patient Stories

Meet some of our inspiring patients who have found renewed health through our cutting-edge integrative and alternative cancer therapies at ICCA Global. Click here to read more.

Eric L.Liver Cancer Patient

"I am absolutely delighted with the results of the FivePOINTS Cancer Care ™ treatment program provided by ICCA Global. My sincerest thanks go to the Doctors and the medical team, who custom designed and administered an amazing treatment plan that, in my mind, could not have been more successful."

TanyaBreast Cancer Patient

"It's been a year and a half, and I'm still clear, and I'm going to stay clear. If I was to ever go for something like that again, I would hands down go back to ICCA Global. They're just one of a kind, truly, from the treatments that's not done anywhere else, to the facility, staff, doctors, everybody involved are just absolutely amazing, five-stars. And I would recommend ICCA any day. If you're hesitant or nervous or scared, don't be, give them a chance. Call them, consult with them. Just know that the place is real and it's amazing. I have no regrets, it was the best decision of my life."

GiannaPatient's Family Member

"My sister came to ICCA Global with colon to liver, to lungs two years ago - and very near death. She is 100% cancer free today."

Bernie B.Patient's Wife

"I brought my husband to ICCA Global for stage 3 lung cancer that spread to the lymph nodes, and he's doing extremely well. He went through three weeks of treatment and he was not sick a day. Not once. Their standards as far as cancer treatment goes, are superior."

* Each patient is unique, and their treatments are tailored accordingly. Individual results will vary. Please consult your doctor before making any changes to your medical treatment. Not every patient is a candidate for care or achieves these results.

What Makes Us Different?

We believe in giving every patient the chance they deserve, even when others have deemed their case as untreatable. Utilizing global modalities, our Primary, Metastatic and Recurrent Cancer Programs are designed to provide access to life-changing therapies that are often unavailable to patients in the U.S. or Canada. As a truly integrated center, not limited by NCCN guidelines, it enables us to personalize cutting-edge alternative therapies with a higher potential of helping you progress towards healing. With affiliates in Southern California and our treatment center in Baja California, Tijuana Mexico, we're always at the forefront of integrative care.

Join us in paving the way for a new era in cancer treatment. Explore a world of possibilities at ICCA Global, where innovation and hope go hand in hand.

Upon arrival, the patient will undergo a real-time PET/CT scan to address the limitations of a CT scan in detecting potential metastatic cancer at the molecular level. This will be followed by a thorough physical examination, comprehensive lab work that includes specific tumor markers, and an aspirated biopsy if necessary.
Unlock the Potential of Off-Label Medications in Immunotherapy
Discover the untapped power of repurposed medications to supercharge your immune response. By utilizing medications traditionally used for other conditions, we can enhance the effectiveness of immunotherapy.


Maximize Immunotherapy Potential with Microbiome Enhancement
Uncover a groundbreaking approach to treating leaky gut syndrome. By enhancing the microbiome, we can unlock the full potential of immunotherapy, leading to improved outcomes for patients.

Conquer Immunotherapy Challenges with Hypoxia Tumor Targeting
Address the root causes of immunosuppression, treatment resistance, tumor growth, and metastasis with hypoxia tumor targeting. This innovative strategy aims to generate global control over these challenges, revolutionizing the field of immunotherapy.

Revolutionize the Tumor Microenvironment with Heat Therapy
Enhance the effectiveness of systemic immunotherapy by "heating up" tumors. By injecting specific immune agents directly into tumors, we can attract immune cells, ensuring optimal treatment results.

Strengthen the Immune System with Autologous Dendritic Cell Vaccine
Prevent the spread of cancer cells and stimulate the immune system with the pioneering autologous dendritic cell vaccine. By training the immune system to recognize and fight invading cancer cells, we can unleash its full potential.

Enhance Healing with Systemic Detoxification
Complement the body's natural healing processes by removing harmful metals and minerals accumulated from external pollutants. Systemic detoxification supports overall health and strengthens the immune system.

Targeted Therapies for Cancer Cells, While Preserving Vital Tissues
Experience the power of toxic-free therapies that selectively target cancer cells without compromising the immune system or causing debilitating side effects. These innovative treatments work in harmony with the body to bolster its defenses.

Precision Testing to Stay One Step Ahead of Immunotherapeutic Escape.
Stay ahead of cancer's adaptive mechanisms and personalize immunotherapy with advanced testing. Discover specific immunotherapies that can overcome escape mechanisms and adapt treatment strategies for better outcomes.
By carefully administering minimal doses of a chemo-sensitizing agent, we can dramatically enhance the overall effectiveness of treatment. With fewer than 10 brief sessions, you'll witness remarkable results while preserving the integrity of surrounding tissues and organs.
Introducing an innovative technique known as tumor ablations, which effectively eradicates a wide range of cancerous tumors by harnessing the power of microwave energy, extreme heat or cold.

Tumor ablations are an alternative to conventional cancer treatment methods such as chemotherapy and surgery, which are invasive and can have debilitating side effects. With ablations, patients can avoid repeated dosing of chemotherapy or the long-term effects of radiation. Tumor ablations are relatively easy and well-tolerated. The recovery time is much faster and less invasive compared to surgery.

Ablation therapy helps to eliminate these tumors locally which prevents tumors from spreading further. Even more, ablation therapy can help to slow the growth of cancerous cells, reduce symptoms and improve the patient's quality of life.

Through this cutting-edge procedure, a surgeon can easily access the tumor by inserting a small laparoscopic port or open incision. To ensure precision, a CT scan or ultrasonic guidance is employed to accurately locate the tumor. Learn more at tumorablations.com.
In the field of precision medicine, there is a need to address the damage caused to cellular tissues and organs by cancer and its treatment. This can be achieved through the replacement, restoration, or revitalization of these compromised areas.

Our approach to supporting this process is through nutritional and supplemental counseling. By analyzing the individual patient's metabolomic signatures using blood-derived mass spectrometry, a comprehensive understanding of their metabolites can be obtained.

This emerging technology has the potential to inform and enhance the practice of precision medicine, offering new possibilities for improving patient outcomes, to repair and rejuvenate cellular tissues and organs that have been affected by cancer or the side effects of cancer treatment.

Healing Starts Here

Global Protocols

Using an array of global modalities, we bring hope to fight cancer with a global approach.

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Live-Cell Tumor Profiling

Did you know that many new therapies fail to deliver on their promises? In fact, a study revealed that only a mere 20% of cancer drugs approved by the FDA actually extended patients' lives. (Source: Gyawali Bishal, Phillips Spencer, Kesselheim, Aaron. Assessment of the Clinical Benefit of Cancer Drugs Receiving Accelerated Approval. JAMA Internal Medicine. 2019 Jul; 179(7): 906–913.)

Through Live-Cell Tumor Profiling, our medical team can identify with great certainty exactly which chemo or chemo combination will work most effectively in killing or at minimum disabling the patient's unique cancer cell's lethal nature by analyzing a very small live tumor sample from each cancer patient.

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Personalized Treatment Plans

We focus on a whole-person approach to care and personalize custom treatment programs based on your unique cancer cells.

Less Toxins

No cutting, no burning, no poisoning. Our neoadjuvant approach aims to shrink or destroy the tumor first prior to removal, to prevent cancer spreading to other parts of the body.

24/7 Care

From inquiry to arrival, our first-class concierge service team will be by your side every step of the way to help you through your healing journey.

LEARN ABOUT THE NEXT STEP FOR YOUR TREATMENT

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Let's explore a world beyond conventional cancer care and unlock endless possibilities for better health. You deserve nothing but the best, and we are here to deliver it to you.

Contact us today and take the first step towards a brighter future.

Restoring Hope. Restoring Life.

Give us a call today to see what our team can do for you and your loved ones.

+1 (949) 939-0050

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Let us know how we can help. Please fill out this confidential form and your Patient Navigator will contact you promptly to discuss your treatment plan options.

Our Center

Discover a beacon of hope for cancer patients at ICCA Global, a premier medical tourism destination in Baja California, Tijuana Mexico. If you or a loved one have experienced the devastating effects of cancer and are tired of mainstream treatments failing or draining your finances, there is a solution. Our cutting-edge alternative medicine offers personalized treatment plans that prioritize your wellbeing. Located near San Diego, our state-of-the-art facility is affiliated with Angeles Hospital, known as one of Mexico's leading hospital chains.

Take charge of your cancer treatment journey today and explore the empowering options available through ICCA Global. Together, let's find a way to overcome the challenges and reclaim hope on your path to healing.